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Peptide record

TPDB64572

TAT-HA2 Cell-penetrating Peptides standard
34 amino acids
Basic Information
3D PDB MODEL
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TPDB64572
TAT-HA2
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0 MLCPP 2.0 Peptipedia PerseuCPP
standard
No
A 34-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, MLCPP 2.0, Peptipedia, and other sources, with an available 3D structural model.
Sequence
YGRKKRRQRRRGLFGAIAGFIENGWEGMIDGWYG
Physicochemical Analysis
C180H274N58O45S1
CHPSTV
G
4002.58
11.28
8
3
13
+5
3.29
-0.926
51.76
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
13980
349.27
4
Residue Composition
number
2
A
6
R
1
N
1
D
0
C
2
E
1
Q
8
G
0
H
3
I
1
L
2
K
1
M
2
F
0
P
0
S
0
T
2
W
2
Y
0
V
Amino Acid Distribution
A: 2 R: 6 N: 1 D: 1 C: 0 E: 2 Q: 1 G: 8 H: 0 I: 3 L: 1 K: 2 M: 1 F: 2 P: 0 S: 0 T: 0 W: 2 Y: 2 V: 0
Chemical Descriptors
34
C180H274N58O45S1
4002.58
11.28
+5
3.29
-0.926
Free
L
Linear
Free
N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)N)C(=O)NCC(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCC(=O)O)C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

PC12 cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
Nanoparticle (Quantum dots)
Cytoplasm
MA
Endocytic pathways
In vitro
CCSCCCCCSCCSCSTTTCCSSCCSBTTBCSTTTC
Additional Detail Fields 1 fields
CCSCCCCCSCCSCSTTTCCSSCCSBTTBCSTTTC