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Peptide record

TPDB64559

TFL541 Cell-penetrating Peptides standard
25 amino acids
Basic Information
3D PDB MODEL
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TPDB64559
TFL541
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 25-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation N-terminal: Acetylation
Sequence
Ac-YGRKKRRQRRRELGEGAFGKVFLAE-NH2
Physicochemical Analysis
C132H219N47O34
NDCHIMPSTW
R
3008.49
11.79
9
3
8
+6
9.92
-1.384
50.80
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
1490
49.53
2
Residue Composition
number
2
A
6
R
0
N
0
D
0
C
3
E
1
Q
4
G
0
H
0
I
2
L
3
K
0
M
2
F
0
P
0
S
0
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 2 R: 6 N: 0 D: 0 C: 0 E: 3 Q: 1 G: 4 H: 0 I: 0 L: 2 K: 3 M: 0 F: 2 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 1
Chemical Descriptors
25
C132H219N47O34
3008.49
11.79
+6
9.92
-1.384
Amidation
L
Linear
Acetylation
N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Rat Primary Neurons From 18-Day-Old Wistar Rat Embryos (E18)

Assay & Model

Ischemia model using cerebral cortex of adult male Balb/cOlaHsd mice (25–30 g 8–12 weeks)
Ischemia model using cerebral cortex of adult male Balb/cOlaHsd mice (25–30 g 8–12 weeks)

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Chimeric
Receptor mediated endocytosis
In vitro and in vivo
CCSCGGGTSCCCGGGTSSSCSSCC
Additional Detail Fields 1 fields
CCSCGGGTSCCCGGGTSSSCSSCC