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Peptide record

TPDB64558

PEP-1 Cell-penetrating Peptides standard
48 amino acids
Basic Information
3D PDB MODEL
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TPDB64558
PEP-1
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0 MLCPP 2.0 Peptipedia
standard
No
A 48-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, MLCPP 2.0, and Peptipedia, with an available 3D structural model.
Sequence
YGRKKRRQRRRDPYHATSGALSPAKDCGSQKYAYFNGCSSPTLSPMSP
Physicochemical Analysis
C230H363N75O69S3
EIWV
S
5379.05
10.53
11
2
12
+8
9.90
-1.262
24.58
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
6085
113.12
18
Residue Composition
number
4
A
6
R
1
N
2
D
2
C
0
E
2
Q
4
G
1
H
0
I
2
L
4
K
1
M
1
F
5
P
7
S
2
T
0
W
4
Y
0
V
Amino Acid Distribution
A: 4 R: 6 N: 1 D: 2 C: 2 E: 0 Q: 2 G: 4 H: 1 I: 0 L: 2 K: 4 M: 1 F: 1 P: 5 S: 7 T: 2 W: 0 Y: 4 V: 0
Chemical Descriptors
48
C230H363N75O69S3
5379.05
10.53
+8
9.90
-1.262
Free
L
Cationic
Linear
Free
N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(=O)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CS)C(=O)/N=C/C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(=O)N)C(=O)NCC(=O)N[C@@H](CS)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

GSC lines (G166, GliNS2, G144, G179), OB1 and TG10 cells

Assay & Model

Albino wistar rats
Albino wistar rats

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Synthetic
Higher uptake efficiency
In vitro and in vivo
CCCSSCSSCCCCSSSSTTTTCCCCCSSCCCCBSCSSSCCSCCCBCCC
Additional Detail Fields 1 fields
CCCSSCSSCCCCSSSSTTTTCCCCCSSCCCCBSCSSSCCSCCCBCCC