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Peptide record

TPDB64555

JNK3-N-Tat Blood-Brain Barrier Cell-penetrating Peptides standard
21 amino acids
Basic Information
3D PDB MODEL
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TPDB64555
JNK3-N-Tat
Blood-Brain Barrier Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
B3Pred BBPpredict Peptipedia CPPsite3.0
standard
No
A 21-aa standard natural multi-activity (Blood-Brain Barrier and Cell-penetrating Peptides) peptide sequence curated from B3Pred, BBPpredict, Peptipedia, and other sources, with an available 3D structural model.
Chemical: JNK3 at N terminal
Sequence
YGRKKRRQRRRCSEPTLDVKI
Physicochemical Analysis
C111H197N43O30S1
ANHMFW
R
2646.12
11.79
9
2
4
+7
10.41
-1.857
50.95
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
1490
56.31
5
Residue Composition
number
0
A
6
R
0
N
1
D
1
C
1
E
1
Q
1
G
0
H
1
I
1
L
3
K
0
M
0
F
1
P
1
S
1
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 0 R: 6 N: 0 D: 1 C: 1 E: 1 Q: 1 G: 1 H: 0 I: 1 L: 1 K: 3 M: 0 F: 0 P: 1 S: 1 T: 1 W: 0 Y: 1 V: 1
Chemical Descriptors
21
C111H197N43O30S1
2646.12
11.79
+7
10.41
-1.857
Free
JNK3 at N terminal
L
Linear
Free
N[C@@H](Cc1ccccc1)C(=O)/N=C/C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

SH-SY5Y Cells

Assay & Model

Eight-week-old male C57BL/6 mice (20–25 g)
Eight-week-old male C57BL/6 mice (20–25 g)

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Fusogenic
Dansyl chloride conjugated
SH-SY5Y cells treated with JNK3-N-Tat-Dansyl exhibited green fluorescence in the cell bod, However, no fluorescence was detected in cells treated with Tat38-48-Dansyl or vehicle alone under ultraviolet laser excitation
In vitro and in vivo
CCTTSSCCCCC
Additional Detail Fields 1 fields
CCTTSSCCCCC