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Peptide record

TPDB64551

PEP-2 Cell-penetrating Peptides standard
29 amino acids
Basic Information
3D PDB MODEL
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TPDB64551
PEP-2
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0 MLCPP 2.0 Peptipedia
standard
No
A 29-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, MLCPP 2.0, and Peptipedia, with an available 3D structural model.
Sequence
YGRKKRRQRRRAYFNGCSSPTAPLSPMSP
Physicochemical Analysis
C144H235N51O39S2
DEHIWV
R
3368.89
12.12
8
0
7
+8
5.94
-1.410
20.34
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
2980
88.46
10
Residue Composition
number
2
A
6
R
1
N
0
D
1
C
0
E
1
Q
2
G
0
H
0
I
1
L
2
K
1
M
1
F
4
P
4
S
1
T
0
W
2
Y
0
V
Amino Acid Distribution
A: 2 R: 6 N: 1 D: 0 C: 1 E: 0 Q: 1 G: 2 H: 0 I: 0 L: 1 K: 2 M: 1 F: 1 P: 4 S: 4 T: 1 W: 0 Y: 2 V: 0
Chemical Descriptors
29
C144H235N51O39S2
3368.89
12.12
+8
5.94
-1.410
Free
L
Cationic
Linear
Free
N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(=O)N)C(=O)NCC(=O)N[C@@H](CS)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

GSC lines (G166, GliNS2, G144, G179), OB1 and TG10 cells

Assay & Model

Albino wistar rats
Albino wistar rats

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Synthetic
Higher uptake efficiency
In vitro and in vivo
CCTTSCCCSCCSCCCSSCSSSCCCCCCCC
Additional Detail Fields 1 fields
CCTTSCCCSCCSCCCSSCSSSCCCCCCCC