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Peptide record

TPDB64549

TMyc Cell-penetrating Peptides standard
25 amino acids
Basic Information
3D PDB MODEL
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TPDB64549
TMyc
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 25-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation N-terminal: Acetylation
Sequence
Ac-YGRKKRRQRRRAEEQKLISEEDLLR-NH2
Physicochemical Analysis
C135H237N51O40
NCHMFPTWV
R
3214.68
11.29
10
5
6
+5
16.15
-2.100
66.40
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
1490
46.35
4
Residue Composition
number
1
A
7
R
0
N
1
D
0
C
4
E
2
Q
1
G
0
H
1
I
3
L
3
K
0
M
0
F
0
P
1
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 1 R: 7 N: 0 D: 1 C: 0 E: 4 Q: 2 G: 1 H: 0 I: 1 L: 3 K: 3 M: 0 F: 0 P: 0 S: 1 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
25
C135H237N51O40
3214.68
11.29
+5
16.15
-2.100
Amidation
L
Linear
Acetylation
N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Rat Primary Neurons From 18-Day-Old Wistar Rat Embryos (E18)

Assay & Model

Ischemia model using cerebral cortex of adult male Balb/cOlaHsd mice (25–30 g 8–12 weeks)
Ischemia model using cerebral cortex of adult male Balb/cOlaHsd mice (25–30 g 8–12 weeks)

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Chimeric
Biotin
83.4% (n = 5) of neurons had internalized TMyc
In vitro and in vivo
CCSSGGGTHHHHSCCCCSSSCCSCC
Additional Detail Fields 1 fields
CCSSGGGTHHHHSCCCCSSSCCSCC