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Peptide record

TPDB64536

1 (TAT) Cell-penetrating Peptides standard
11 amino acids
Basic Information
3D PDB MODEL
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TPDB64536
1 (TAT)
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0 MLCPP 2.0 Peptipedia PerseuCPP
standard
No
A 11-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, MLCPP 2.0, Peptipedia, and other sources, with an available 3D structural model.
Sequence
YGRKKRPQRRR
Physicochemical Analysis
C63H113N29O14
ANDCEHILMFSTWV
R
1500.78
12.58
7
0
1
+7
6.13
-3.373
0.00
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
1490
99.28
2
Residue Composition
number
0
A
5
R
0
N
0
D
0
C
0
E
1
Q
1
G
0
H
0
I
0
L
2
K
0
M
0
F
1
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 5 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 1 H: 0 I: 0 L: 0 K: 2 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
11
C63H113N29O14
1500.78
12.58
+7
6.13
-3.373
L
Cationic
Linear
N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Many Human neoplastic cells including HeLa, Lovo, A549, MCF-7,MKN45,HepG2, LNCap, KPK,U2OS, RC-15,RD-ES,H28,K562,U251,NHDF

Assay & Model

NOD-SCID mice model of xenograft human tumour cells
NOD-SCID mice model of xenograft human tumour cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Protein derived
Fluorophore (FITC)
low penetration into normal fibroblasts
In vitro and in vivo
CCSCCCGGGTC
Additional Detail Fields 1 fields
CCSCCCGGGTC