Back to search

Peptide record

TPDB64533

A5 Cell-penetrating Peptides standard
11 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB64533
A5
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 11-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation Chemical: Glu-Lys stapled N-terminal: Conjugated with FITC
Sequence
YGRKERRQKRR-NH2
Physicochemical Analysis
C63H113N29O16
ANDCHILMFPSTWV
R
1532.78
12.24
7
1
1
+6
7.70
-3.545
0.00
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
1490
97.21
2
Residue Composition
number
0
A
5
R
0
N
0
D
0
C
1
E
1
Q
1
G
0
H
0
I
0
L
2
K
0
M
0
F
0
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 5 N: 0 D: 0 C: 0 E: 1 Q: 1 G: 1 H: 0 I: 0 L: 0 K: 2 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
11
C63H113N29O16
1532.78
12.24
+6
7.70
-3.545
Amidation
Glu-Lys stapled
L
Cationic and amphipathic
Stapled
Conjugated with FITC
N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa And MCF-7 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Stapled L Cationic and amphipathic
Synthetic
FITC dye
Less active than that of A1
In vitro
CCCSCHHHHHHHTTCC
Additional Detail Fields 1 fields
CCCSCHHHHHHHTTCC