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Peptide record

TPDB64517

Dynorphin A (DynA) Cell-penetrating Peptides standard
17 amino acids
Basic Information
3D PDB MODEL
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TPDB64517
Dynorphin A (DynA)
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 17-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
YGGFLRRIRPKLKYDNQ
Physicochemical Analysis
C97H154N30O24
ACEHMSTWV
R
2124.48
10.79
5
1
6
+4
2.67
-1.288
68.82
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
2980
140.27
4
Residue Composition
number
0
A
3
R
1
N
1
D
0
C
0
E
1
Q
2
G
0
H
1
I
2
L
2
K
0
M
1
F
1
P
0
S
0
T
0
W
2
Y
0
V
Amino Acid Distribution
A: 0 R: 3 N: 1 D: 1 C: 0 E: 0 Q: 1 G: 2 H: 0 I: 1 L: 2 K: 2 M: 0 F: 1 P: 1 S: 0 T: 0 W: 0 Y: 2 V: 0
Chemical Descriptors
17
C97H154N30O24
2124.48
10.79
+4
2.67
-1.288
Free
L
Amphipathic
Linear
Free
N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)O)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Neutral PhosphatidylCHOline (Pc) Membranes

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Amphipathic
Protein derived
DynA generates two kinds of permeabilization events in neutral membranes ion channel-like pores and voltage-driven transport.
Direct translocation
In vitro
CCHHHHHHHHHHHSCCTTC
Additional Detail Fields 1 fields
CCHHHHHHHHHHHSCCTTC