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Peptide record

TPDB64513

GK2 PTD Cell-penetrating Peptides standard
18 amino acids
Basic Information
3D PDB MODEL
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TPDB64513
GK2 PTD
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 18-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
YAYRIREFRQTFRKIIRS
Physicochemical Analysis
C110H175N35O26
NDCGHLMPWV
R
2403.82
11.84
6
1
8
+5
2.67
-0.922
70.56
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
2980
123.97
5
Residue Composition
number
1
A
5
R
0
N
0
D
0
C
1
E
1
Q
0
G
0
H
3
I
0
L
1
K
0
M
2
F
0
P
1
S
1
T
0
W
2
Y
0
V
Amino Acid Distribution
A: 1 R: 5 N: 0 D: 0 C: 0 E: 1 Q: 1 G: 0 H: 0 I: 3 L: 0 K: 1 M: 0 F: 2 P: 0 S: 1 T: 1 W: 0 Y: 2 V: 0
Chemical Descriptors
18
C110H175N35O26
2403.82
11.84
+5
2.67
-0.922
Free
L
Linear
Free
N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CS)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

SH-SY5Y, Ht-22, RAW 264.7 And Rinm5F

Assay & Model

Eight-week-old, male C57BL/6 mice
Eight-week-old, male C57BL/6 mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Protein derived
Biliverdin reductase A (BLVRA)
Cytoplasm and nucleus
GK2-BLVRA protein green fluorescence levels were higher than Tat-BLVRA protein.
In vitro and in vivo
CCHHHHHHHHHHHHCGGGSCCSCCC
Additional Detail Fields 1 fields
CCHHHHHHHHHHHHCGGGSCCSCCC