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Peptide record

TPDB64511

Hph-1-PTD Cell-penetrating Peptides standard
11 amino acids
Basic Information
3D PDB MODEL
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TPDB64511
Hph-1-PTD
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0 MLCPP 2.0 Peptipedia PerseuCPP
standard
No
A 11-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, MLCPP 2.0, Peptipedia, and other sources, with an available 3D structural model.
Sequence
YARVRRRGPRR
Physicochemical Analysis
C60H107N29O13
NDCEQHILKMFSTW
R
1442.70
12.70
6
0
3
+6
4.28
-2.209
35.45
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
1490
103.28
1
Residue Composition
number
1
A
6
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
0
I
0
L
0
K
0
M
0
F
1
P
0
S
0
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 1 R: 6 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 1 V: 1
Chemical Descriptors
11
C60H107N29O13
1442.70
12.70
+6
4.28
-2.209
Free
L
Cationic and amphipathic
Linear
Free
N[C@@H](Cc1ccccc1)C(=O)/N=C/C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 3 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa, Hepg2 Cells

Assay & Model

Dorsal skin of 5-week-old hairless mouse (BALB/c nude female mice
Dorsal skin of 5-week-old hairless mouse (BALB/c nude female mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Non-natural residues Linear L Cationic and amphipathic
Protein derived
Ubiquinol–cytochrome c reductase binding protein (UQCRB)
Mitochondria
Efficient and dose-dependent internalization
In vitro and in vivo
Evidence 2 Activity

Activity

Cell-penetrating Peptides

Target

Th17 Cells , Jurkat Cells ,HeLa Cells, Mouse Cd4+ T Cells

Assay & Model

Female C57BL/6 mice (6-week-old)
Female C57BL/6 mice (6-week-old)

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L
Protein derived
ntHIF-1α-TMD domain of HIF-1α
Nucleus
Dose- and time-dependent internalization
In vitro and in vivo
CCTTSSCCCCC
Evidence 3 Activity

Activity

Cell-penetrating Peptides

Target

HeLa And 293T Cells,

Assay & Model

7- to 8-week-old female BALB/c and C57BL/6
7- to 8-week-old female BALB/c and C57BL/6

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L
Protein derived
GATA3-transcription modulation domain (TMD) (ndG3-TMD)
Cytoplasm and nucleus
Dose- and time-dependent internalization
In vitro and in vivo
CCCSTTCCCC
Additional Detail Fields 1 fields
CCTTSSCCCCC CCCSTTCCCC