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Peptide record

TPDB64504

PTD4 Cell-penetrating Peptides standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB64504
PTD4
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 12-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Addition of Cysteine
Sequence
YARAAARQARAC
Physicochemical Analysis
C53H90N22O15S1
NDEGHILKMFPSTWV
A
1307.50
11.07
3
0
7
+3
0.81
-0.417
50.00
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
1490
113.96
3
Residue Composition
number
6
A
3
R
0
N
0
D
1
C
0
E
1
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 6 R: 3 N: 0 D: 0 C: 1 E: 0 Q: 1 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
12
C53H90N22O15S1
1307.50
11.07
+3
0.81
-0.417
Addition of Cysteine
L
Cationic
Linear
Free
N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C)C(=O)N[C@@H](CS)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

CHO Cells

Assay & Model

Six-week-old male nude mice (BALB/c nu/nu) bearing NCI-N87 and PANC-1 tumors
Six-week-old male nude mice (BALB/c nu/nu) bearing NCI-N87 and PANC-1 tumors

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Synthetic
Indocyanine green (ICG)-labeled Lactosomes (A3B-type)
In vitro and in vivo
CCCCTTSCCCCC
Additional Detail Fields 1 fields
CCCCTTSCCCCC