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Peptide record

TPDB64490

TP10 (F-1) Cell-penetrating Peptides modified_plain modified
22 amino acids
Basic Information
3D PDB MODEL
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TPDB64490
TP10 (F-1)
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
modified_plain
Yes
A 22-aa modified cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation Chemical: X= β-alanine
Sequence
XAGYLLGKINLKALAALAKKIL-NH2
Physicochemical Analysis
C104H184N26O24
RDCEQHMFPSTWV
L
2182.76
10.64
4
0
14
+4
-1.37
0.891
164.55
Mammalian: Yeast: E.coli:
1490
68.26
2
Residue Composition
number
5
A
0
R
1
N
0
D
0
C
0
E
0
Q
2
G
0
H
2
I
6
L
4
K
0
M
0
F
0
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 5 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 2 L: 6 K: 4 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
22
C104H184N26O24
2182.76
10.64
+4
-1.37
0.891
Amidation
X= β-alanine
Modified
Hydrophobic
Linear
Free
N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 2 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Hek293 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear Modified Hydrophobic
Protein derived
5(6)-carboxyfluorescein (CF) at N terminus
F-1, exhibited a decrease in intracellular fluorescence intensity over time.
Endocytosis
In vitro
CTTCTTCCCCCC
Evidence 2 Activity

Activity

Cell-penetrating Peptides

Target

Hek293 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Non-natural residues Linear Modified Hydrophobic
Protein derived
Cy5-labeled pDNA
Endocytosis
In vitro
Additional Detail Fields 1 fields
CTTCTTCCCCCC