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Peptide record

TPDB64488

W4R4 P4 Cell-penetrating Peptides standard
8 amino acids
Basic Information
3D PDB MODEL
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TPDB64488
W4R4 P4
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 8-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
WWWWRRRR
Physicochemical Analysis
C68H90N24O9
ANDCEQGHILKMFPSTYV
RW
1387.62
12.88
4
0
4
+4
-4.16
-2.700
0.00
Mammalian: 2.8 hour Yeast: 3 min E.coli: 2 min
22000
1585.45
0
Residue Composition
number
0
A
4
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
4
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 4 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 4 Y: 0 V: 0
Chemical Descriptors
8
C68H90N24O9
1387.62
12.88
+4
-4.16
-2.700
Free
L
Amphipathic Cationic and amphiphilic
Linear
Free
N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 2 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Raji Cell

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Amphipathic
Synthetic
Methotrexate
In vitro
CCBCSSCBCTTTTC
Evidence 2 Activity

Activity

Cell-penetrating Peptides

Target

A549 Cell

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Cationic and amphiphilic
Synthetic
Rhodamine123, Doxorubicin
In vitro
CCCCCC
Additional Detail Fields 1 fields
CCBCSSCBCTTTTC CCCCCC