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Peptide record

TPDB64483

W3R4W3-E12 Cell-penetrating Peptides standard
22 amino acids
Basic Information
3D PDB MODEL
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TPDB64483
W3R4W3-E12
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 22-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
WWWRRRRWWWEEEEEEEEEEEE
Physicochemical Analysis
C150H194N40O47
ANDCQGHILKMFPSTYV
E
3309.43
3.95
4
12
6
-8
16.38
-2.973
0.00
Mammalian: 2.8 hour Yeast: 3 min E.coli: 2 min
33000
997.15
0
Residue Composition
number
0
A
4
R
0
N
0
D
0
C
12
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
6
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 4 N: 0 D: 0 C: 0 E: 12 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 6 Y: 0 V: 0
Chemical Descriptors
22
C150H194N40O47
3309.43
3.95
-8
16.38
-2.973
Free
L
Amphipathic
Linear
Free
N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

MCF-7 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Amphipathic
Synthetic
FITC dye and Methotrexate (MTX)
Low cellular uptake
In vitro
CCHHHHHHIIIIITTC
Additional Detail Fields 1 fields
CCHHHHHHIIIIITTC