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Peptide record

TPDB64474

CPP5 Cell-penetrating Peptides standard
10 amino acids
Basic Information
3D PDB MODEL
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TPDB64474
CPP5
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 10-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation Chemical: IR780-labeled usNLCs
Sequence
WWRKFWRWLK-NH2
Physicochemical Analysis
C83H110N22O11
ANDCEQGHIMPSTYV
W
1591.93
12.42
4
0
6
+4
-5.49
-1.380
39.00
Mammalian: 2.8 hour Yeast: 3 min E.coli: 2 min
22000
1381.97
0
Residue Composition
number
0
A
2
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
1
L
2
K
0
M
1
F
0
P
0
S
0
T
4
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 1 K: 2 M: 0 F: 1 P: 0 S: 0 T: 0 W: 4 Y: 0 V: 0
Chemical Descriptors
10
C83H110N22O11
1591.93
12.42
+4
-5.49
-1.380
Amidation
IR780-labeled usNLCs
L
Linear
Free
N[C@@H](CS)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Hbmec Cell Monolayer And U87 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
Celecoxib (CXB)
Uptake across the BBB = CPP4 > CPP2 >CPP3 > CPP5 > c(RGDfK) > CPP3. CPP1, CPP2, CPP3, CPP5, and c(RGDfK) demonstrated higher uptake efficiency in the U87 cell membrane.
Non-dependent energy pathway (e.g., direct translocation).
In vitro and ex vivo
CCCHHHHHHHHHHSCCC
Additional Detail Fields 1 fields
CCCHHHHHHHHHHSCCC