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Peptide record

TPDB64461

[WR]9 Cell-penetrating Peptides standard
18 amino acids
Basic Information
3D PDB MODEL
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TPDB64461
[WR]9
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 18-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
WRWRWRWRWRWRWRWRWR
Physicochemical Analysis
C153H200N54O19
ANDCEQGHILKMFPSTYV
RW
3099.62
13.30
9
0
9
+9
-9.36
-2.700
0.00
Mammalian: 2.8 hour Yeast: 3 min E.coli: 2 min
49500
1596.97
0
Residue Composition
number
0
A
9
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
9
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 9 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 9 Y: 0 V: 0
Chemical Descriptors
18
C153H200N54O19
3099.62
13.30
+9
-9.36
-2.700
Free
L
Cationic
Cyclic
Free
N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCN=C)C(=O)O N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCCN)C(=O)O N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 4 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

CCRF-CEM And Llc-Pk1 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Cyclic L Cationic
Synthetic
CF-labelled phosphopeptide (GpYEEI)
[WR]9 (10 μM) significantly enhanced the cellular uptake of F′-GpYEEI (2 μM) by 20-fold with alone F′-GpYEEI and 4 -fold with [WR]5-GpYEEI (2 μM).
In vitro
CCCSSCCSCCCCCSCC
Evidence 2 Activity

Activity

Cell-penetrating Peptides

Target

CCRF-CEM And Llc-Pk1 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Cyclic L Cationic
Synthetic
CF-labelled stavudine (d4T)
Significantly enhanced the cellular uptake of F′-d4T by 2-fold
In vitro
CCCCCSSSSCCSCCCSCC
Evidence 3 Activity

Activity

Cell-penetrating Peptides

Target

CCRF-CEM And Llc-Pk1 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Cyclic L Cationic
Synthetic
CF-labelled emtricitabine (FTC)
Significantly enhanced the cellular uptake of F′-FTC with [WR]9 enhanced the uptake only by 1.75- fold
In vitro
CCCCCCCSSCCCCCCSCC
Evidence 4 Activity

Activity

Cell-penetrating Peptides

Target

CCRF-CEM And Llc-Pk1 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Cyclic L Cationic
Synthetic
CF-labelled lamivudine (3TC)
Significantly enhanced the cellular uptake of F′-3TC by 2-fold
In vitro
CCCCCCCSSCCCCCCSCC
Additional Detail Fields 1 fields
CCCSSCCSCCCCCSCC CCCCCSSSSCCSCCCSCC CCCCCCCSSCCCCCCSCC