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Peptide record

TPDB64460

[W9R8K] Cell-penetrating Peptides standard
18 amino acids
Basic Information
3D PDB MODEL
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TPDB64460
[W9R8K]
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 18-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
WRWRWRWRWRWRWRWRWK
Physicochemical Analysis
C153H200N52O19
ANDCEQGHILMFPSTYV
W
3071.61
13.25
9
0
9
+9
-9.18
-2.667
0.00
Mammalian: 2.8 hour Yeast: 3 min E.coli: 2 min
49500
1611.53
0
Residue Composition
number
0
A
8
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
1
K
0
M
0
F
0
P
0
S
0
T
9
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 8 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 1 M: 0 F: 0 P: 0 S: 0 T: 0 W: 9 Y: 0 V: 0
Chemical Descriptors
18
C153H200N52O19
3071.61
13.25
+9
-9.18
-2.667
Free
L
Cationic
Cyclic
Free
N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

CCRF-CEM And Llc-Pk1 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Cyclic L Cationic
Synthetic
CF-labelled phosphopeptide (GpYEEI)
Cytoplasm and nucleus
The cellular uptake of F′-[W9R8K] was significantly enhanced in a concentration dependent manner with the highest uptake at 10 μM.
Clathrin-mediated or caveolae-mediated endocytosis and Others
In vitro
CCCCCCCSSCCCCCCSCC
Additional Detail Fields 1 fields
CCCCCCCSSCCCCCCSCC