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Peptide record

TPDB64449

cyclic [W(RW)4] Cell-penetrating Peptides standard
8 amino acids
Basic Information
3D PDB MODEL
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TPDB64449
cyclic [W(RW)4]
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0 MLCPP 2.0 Peptipedia PerseuCPP
standard
No
A 8-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, MLCPP 2.0, Peptipedia, and other sources, with an available 3D structural model.
Chemical: Drug conjugated with peptide through linker
Sequence
WRWKKKKA
Physicochemical Analysis
C55H87N17O9
NDCEQGHILMFPSTYV
K
1130.40
11.80
5
0
3
+5
0.90
-2.512
12.50
Mammalian: 2.8 hour Yeast: 3 min E.coli: 2 min
11000
973.10
0
Residue Composition
number
1
A
1
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
4
K
0
M
0
F
0
P
0
S
0
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 4 M: 0 F: 0 P: 0 S: 0 T: 0 W: 2 Y: 0 V: 0
Chemical Descriptors
8
C55H87N17O9
1130.40
11.80
+5
0.90
-2.512
Drug conjugated with peptide through linker
L
Cationic
Cyclic
N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

MDA-MB-468, HCT-116, CCRF-CEM, and SK-OV-3

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Cyclic L Cationic
Synthetic
Small molecule drug (Doxorubicin)
Nucleus
Higher than (RW)4
In vitro
CCCTTCCC
Additional Detail Fields 1 fields
CCCTTCCC