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Peptide record

TPDB64444

peptide pair 6 Cell-penetrating Peptides standard
16 amino acids
Basic Information
3D PDB MODEL
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TPDB64444
peptide pair 6
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 16-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Chemical: Nanoparticle
Sequence
WRLWRLLRRLARALRA
Physicochemical Analysis
C97H164N36O17
NDCEQGHIKMFPSTYV
R
2106.60
13.10
6
0
10
+6
-2.15
-0.275
140.62
Mammalian: 2.8 hour Yeast: 3 min E.coli: 2 min
11000
522.17
0
Residue Composition
number
3
A
6
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
5
L
0
K
0
M
0
F
0
P
0
S
0
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 3 R: 6 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 5 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 2 Y: 0 V: 0
Chemical Descriptors
16
C97H164N36O17
2106.60
13.10
+6
-2.15
-0.275
Free
Nanoparticle
L
Cationic and amphipathic
Linear
Free
N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

MCF-7 And MDA-MB-231 Breast Cancer Cells Pc-3 And Du145 Prostate Cancer Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic and amphipathic
Synthetic
pEGFP-N1
Pep 5 and 6 were not any more efficient than naked DNA in MDA-MB-231.
In vitro
CCTHHHHTTTHHHHTC
Additional Detail Fields 1 fields
CCTHHHHTTTHHHHTC