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Peptide record

TPDB64436

PN291 (SEQ ID NO: 80) Cell-penetrating Peptides standard
20 amino acids
Basic Information
3D PDB MODEL
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TPDB64436
PN291 (SEQ ID NO: 80)
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CellPPD CellPPD-MOD CPPsite3.0 MLCPP 2.0 Peptipedia
standard
No
A 20-aa standard natural cell-penetrating peptides peptide sequence curated from CellPPD, CellPPD-MOD, CPPsite3.0, and other sources, with an available 3D structural model.
C-terminal: Amidation N-terminal: Maleimide addition
Sequence
WRFKAAVALLPAVLLALLAP-NH2
Physicochemical Analysis
C106H173N25O21
NDCEQGHIMSTY
AL
2133.69
11.49
2
0
16
+2
-4.52
1.615
176.00
Mammalian: 2.8 hour Yeast: 3 min E.coli: 2 min
5500
257.77
0
Residue Composition
number
6
A
1
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
6
L
1
K
0
M
1
F
2
P
0
S
0
T
1
W
0
Y
2
V
Amino Acid Distribution
A: 6 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 6 K: 1 M: 0 F: 1 P: 2 S: 0 T: 0 W: 1 Y: 0 V: 2
Chemical Descriptors
20
C106H173N25O21
2133.69
11.49
+2
-4.52
1.615
Amidation
L
Linear
Maleimide addition
N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

9 L/LacZ cells

Source & Reference

CPPsite3.0
CPPsite3
US 20060035815

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
Nucleic acid (siRNA)
In vitro
CCCCCHHHHTHHHHTTTSCC
Additional Detail Fields 1 fields
CCCCCHHHHTHHHHTTTSCC