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Peptide record

TPDB64432

CMP (cardiomyocyte specific peptide) Cell-penetrating Peptides standard
20 amino acids
Basic Information
3D PDB MODEL
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TPDB64432
CMP (cardiomyocyte specific peptide)
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 20-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Chemical: DSPE-PEG
Sequence
WLSEAGPVVTVRALRGTGSW
Physicochemical Analysis
C97H152N28O27
NDCQHIKMFY
GV
2142.45
10.89
2
1
9
+1
-0.29
0.185
92.50
Mammalian: 2.8 hour Yeast: 3 min E.coli: 2 min
11000
513.43
4
Residue Composition
number
2
A
2
R
0
N
0
D
0
C
1
E
0
Q
3
G
0
H
0
I
2
L
0
K
0
M
0
F
1
P
2
S
2
T
2
W
0
Y
3
V
Amino Acid Distribution
A: 2 R: 2 N: 0 D: 0 C: 0 E: 1 Q: 0 G: 3 H: 0 I: 0 L: 2 K: 0 M: 0 F: 0 P: 1 S: 2 T: 2 W: 2 Y: 0 V: 3
Chemical Descriptors
20
C97H152N28O27
2142.45
10.89
+1
-0.29
0.185
Free
DSPE-PEG
L
Linear
Free
NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

H9C2 Cardiomyocytes

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
BMSC-derived exosomes and miR302 mimics
Cardiomyocytes exhibited increased uptake of DSPE-PEG-CMP-EXO when compared with unmodified-EXO , showed an increased miR302 level.
Endocytosis
In vitro
CHHHHHHHHHHHHHHHHTC
Additional Detail Fields 1 fields
CHHHHHHHHHHHHHHHHTC