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Peptide record

TPDB64430

MK2i Cell-penetrating Peptides standard
23 amino acids
Basic Information
3D PDB MODEL
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TPDB64430
MK2i
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CellPPD CPPsite3.0 MLCPP 2.0 Peptipedia
standard
No
A 23-aa standard natural cell-penetrating peptides peptide sequence curated from CellPPD, CPPsite3.0, MLCPP 2.0, and other sources, with an available 3D structural model.
Sequence
WLRRIKAWLRRIKALNRQLGVAA
Physicochemical Analysis
C128H218N44O26
DCEHMFPSTY
R
2789.42
13.01
7
0
13
+7
-0.13
-0.170
131.74
Mammalian: 2.8 hour Yeast: 3 min E.coli: 2 min
11000
394.35
2
Residue Composition
number
4
A
5
R
1
N
0
D
0
C
0
E
1
Q
1
G
0
H
2
I
4
L
2
K
0
M
0
F
0
P
0
S
0
T
2
W
0
Y
1
V
Amino Acid Distribution
A: 4 R: 5 N: 1 D: 0 C: 0 E: 0 Q: 1 G: 1 H: 0 I: 2 L: 4 K: 2 M: 0 F: 0 P: 0 S: 0 T: 0 W: 2 Y: 0 V: 1
Chemical Descriptors
23
C128H218N44O26
2789.42
13.01
+7
-0.13
-0.170
Free
L
Linear
Free
N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)O N[C@@H](Cc1ccccc1)C(=O)/N=C/C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 2 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Human keloid fibroblasts

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Protein derived
In vitro
CCSCHHHHHHHHHHHTTTSSCCC
Evidence 2 Activity

Activity

Cell-penetrating Peptides

Target

Sf9 And Rp-Hzgut-Aw1 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L
Synthetic
STAR635P fluorophore
Cytoplasm
Rapid uptake of CPP through endosomes as Fluorescent vesicles were observed in as little as 20 min and were significantly high compared to the control.
Endocytosis and diffusion
In vitro and ex vivo
CCTTSSCCCCC
Additional Detail Fields 1 fields
CCSCHHHHHHHHHHHTTTSSCCC CCTTSSCCCCC