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Peptide record

TPDB64429

PepFect 52 Cell-penetrating Peptides standard
31 amino acids
Basic Information
3D PDB MODEL
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TPDB64429
PepFect 52
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 31-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation N-terminal: Stearylation
Sequence
WLRLWRRWLRLWTFFYGGSRGKRNNFKTEEY-NH2
Physicochemical Analysis
C196H281N57O43
ADCQHIMPV
R
4123.74
11.77
8
2
13
+6
-2.75
-1.123
50.32
Mammalian: 2.8 hour Yeast: 3 min E.coli: 2 min
24980
605.76
7
Residue Composition
number
0
A
6
R
2
N
0
D
0
C
2
E
0
Q
3
G
0
H
0
I
4
L
2
K
0
M
3
F
0
P
1
S
2
T
4
W
2
Y
0
V
Amino Acid Distribution
A: 0 R: 6 N: 2 D: 0 C: 0 E: 2 Q: 0 G: 3 H: 0 I: 0 L: 4 K: 2 M: 0 F: 3 P: 0 S: 1 T: 2 W: 4 Y: 2 V: 0
Chemical Descriptors
31
C196H281N57O43
4123.74
11.77
+6
-2.75
-1.123
Amidation
L
Amphipathic
Linear
Stearylation
N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

U87 Mg-Luc2 And HeLa-Luc Cell Lines

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Amphipathic
Synthetic
Double-stranded siRNA luc
Cytosol
In vitro
CCTTHHHHHHHHTTCCTTSCCBTTTBCSSCC
Additional Detail Fields 1 fields
CCTTHHHHHHHHTTCCTTSCCBTTTBCSSCC