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Peptide record

TPDB64422

PepFect 51 Cell-penetrating Peptides standard
31 amino acids
Basic Information
3D PDB MODEL
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TPDB64422
PepFect 51
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 31-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation N-terminal: Stearylation
Sequence
WLKLWKKWLKLWTFFYGGSRGKRNNFKTEEY-NH2
Physicochemical Analysis
C196H281N49O43
ADCQHIMPV
K
4011.69
10.64
8
2
13
+6
-2.03
-1.045
50.32
Mammalian: 2.8 hour Yeast: 3 min E.coli: 2 min
24980
622.68
7
Residue Composition
number
0
A
2
R
2
N
0
D
0
C
2
E
0
Q
3
G
0
H
0
I
4
L
6
K
0
M
3
F
0
P
1
S
2
T
4
W
2
Y
0
V
Amino Acid Distribution
A: 0 R: 2 N: 2 D: 0 C: 0 E: 2 Q: 0 G: 3 H: 0 I: 0 L: 4 K: 6 M: 0 F: 3 P: 0 S: 1 T: 2 W: 4 Y: 2 V: 0
Chemical Descriptors
31
C196H281N49O43
4011.69
10.64
+6
-2.03
-1.045
Amidation
L
Amphipathic
Linear
Stearylation
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

U87 Mg-Luc2 And HeLa-Luc Cell Lines

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Non-natural residues Linear L Amphipathic
Synthetic
Double-stranded siRNA luc
Cytosol
Most efficient gene-silencing with 50% and 60% downregulation at molar ratio 20 and 50
In vitro