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Peptide record

TPDB64421

PepFect 53 Cell-penetrating Peptides standard
22 amino acids
Basic Information
3D PDB MODEL
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TPDB64421
PepFect 53
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 22-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation N-terminal: Stearylation
Sequence
WLKLWKKWLKLWACGLSGLGVA-NH2
Physicochemical Analysis
C127H194N30O24S1
RNDEQHIMFPTY
L
2557.18
10.55
4
0
13
+4
-7.15
0.541
128.64
Mammalian: 2.8 hour Yeast: 3 min E.coli: 2 min
22000
860.32
2
Residue Composition
number
2
A
0
R
0
N
0
D
1
C
0
E
0
Q
3
G
0
H
0
I
6
L
4
K
0
M
0
F
0
P
1
S
0
T
4
W
0
Y
1
V
Amino Acid Distribution
A: 2 R: 0 N: 0 D: 0 C: 1 E: 0 Q: 0 G: 3 H: 0 I: 0 L: 6 K: 4 M: 0 F: 0 P: 0 S: 1 T: 0 W: 4 Y: 0 V: 1
Chemical Descriptors
22
C127H194N30O24S1
2557.18
10.55
+4
-7.15
0.541
Amidation
L
Amphipathic
Linear
Stearylation
N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

U87 Mg-Luc2 And HeLa-Luc Cell Lines

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Amphipathic
Synthetic
Double-stranded siRNA luc
Cytosol
In vitro
CCSSHHHHHHHHTTTCTTSCCBTTTBCSSCC
Additional Detail Fields 1 fields
CCSSHHHHHHHHTTTCTTSCCBTTTBCSSCC