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Peptide record

TPDB64414

NrTP8 Cell-penetrating Peptides standard
14 amino acids
Basic Information
3D PDB MODEL
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TPDB64414
NrTP8
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0 Peptipedia PerseuCPP
standard
No
A 14-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, Peptipedia, and PerseuCPP, with an available 3D structural model.
N-terminal: Conjugation with rhodamine B
Sequence
WKQSHKKGGKKGSG
Physicochemical Analysis
C66H109N23O18
ARNDCEILMFPTYV
K
1512.73
11.12
6
0
1
+5
4.94
-2.164
0.00
Mammalian: 2.8 hour Yeast: 3 min E.coli: 2 min
5500
363.58
3
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
1
Q
4
G
1
H
0
I
0
L
5
K
0
M
0
F
0
P
2
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 4 H: 1 I: 0 L: 0 K: 5 M: 0 F: 0 P: 0 S: 2 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
14
C66H109N23O18
1512.73
11.12
+5
4.94
-2.164
Free
L
Linear
Conjugation with rhodamine B
N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CO)C(=O)NCC(=O)O
Evidence Records 2 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

PBMCs

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
Fluorophore (Rhodamine B)
Endocytic pathway
In vitro
CCSSSCCCCCSCC
Evidence 2 Activity

Activity

Cell-penetrating Peptides

Target

Hela, Molt-4 and erythrocytes

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L
Protein derived
Fluorophore (Rhodamine B )
Cytoplasm and nucleus
In vitro
CCSSSCCCCCSCC
Additional Detail Fields 1 fields
CCSSSCCCCCSCC