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Peptide record

TPDB64412

PF224 Cell-penetrating Peptides standard
16 amino acids
Basic Information
3D PDB MODEL
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TPDB64412
PF224
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 16-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation Chemical: Magnetic nanoparticles (MNPs) N-terminal: Stearylation
Sequence
WKKWINLKALINLKAL-NH2
Physicochemical Analysis
C96H158N24O19
RDCEQGHMFPSTYV
LK
1952.46
11.00
4
0
10
+4
-2.10
0.213
158.75
Mammalian: 2.8 hour Yeast: 3 min E.coli: 2 min
11000
563.39
2
Residue Composition
number
2
A
0
R
2
N
0
D
0
C
0
E
0
Q
0
G
0
H
2
I
4
L
4
K
0
M
0
F
0
P
0
S
0
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 2 R: 0 N: 2 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 2 L: 4 K: 4 M: 0 F: 0 P: 0 S: 0 T: 0 W: 2 Y: 0 V: 0
Chemical Descriptors
16
C96H158N24O19
1952.46
11.00
+4
-2.10
0.213
Amidation
Magnetic nanoparticles (MNPs)
L
Linear
Stearylation
NCC(=O)N[C@@H](CC(=O)N)C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

U-87 Mg-Luc2, HeLa Pulc 705

Assay & Model

Mice
Mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
Plasmid (pGL3, splicing correcting oligonucleotides (SCO), and small interfering RNA (siRNA)
In vitro
CCSSSCCTTGGGTHHHHGGGC
Additional Detail Fields 1 fields
CCSSSCCTTGGGTHHHHGGGC