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Peptide record

TPDB64409

CPP48 Cell-penetrating Peptides Tumor-homing Peptides standard
15 amino acids
Basic Information
3D PDB MODEL
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TPDB64409
CPP48
Cell-penetrating Peptides Tumor-homing Peptides
Cancer-related peptides Delivery and barrier-penetrating peptides
CPPsite3.0 MLCPP 2.0 Peptipedia PerseuCPP TumorHoPe2.0
standard
No
A 15-aa standard natural multi-activity (Cell-penetrating Peptides and Tumor-homing Peptides) peptide sequence curated from CPPsite3.0, MLCPP 2.0, Peptipedia, and other sources, with an available 3D structural model.
Sequence
WKARRQCFRVLHHWN
Physicochemical Analysis
C93H137N33O18S1
DEGIMPSTY
R
2037.38
12.12
6
0
6
+4
0.61
-1.167
52.00
Mammalian: 2.8 hour Yeast: 3 min E.coli: 2 min
11000
539.91
3
Residue Composition
number
1
A
3
R
1
N
0
D
1
C
0
E
1
Q
0
G
2
H
0
I
1
L
1
K
0
M
1
F
0
P
0
S
0
T
2
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 3 N: 1 D: 0 C: 1 E: 0 Q: 1 G: 0 H: 2 I: 0 L: 1 K: 1 M: 0 F: 1 P: 0 S: 0 T: 0 W: 2 Y: 0 V: 1
Chemical Descriptors
15
C93H137N33O18S1
2037.38
12.12
+4
0.61
-1.167
L
Linear
N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CS)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CC(=O)N)C(=O)O
Evidence Records 2 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Many Human neoplastic cells including HeLa, Lovo, A549, MCF-7,MKN45,HepG2, LNCap, KPK,U2OS, RC-15,RD-ES,H28,K562,U251,NHDF

Assay & Model

NOD-SCID mice model of xenograft human tumour cells
NOD-SCID mice model of xenograft human tumour cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
Fluorophore (FITC)
In vitro and in vivo
CIIIIISGGGSCC
Evidence 2 Activity

Activity

Tumor-homing Peptides

Target

Homing
Hematopoietic malignancies

Source & Reference

TumorHoPe2.0
TumorHoPe2
Tumour lineage-homing cell-penetrating peptides as anticancer molecular delivery systems
2012
Eisaku Kondo et al. Nat Commun. 2012 Jul 17:3:951.

Other

Source Activity Label Source Definition
Tumor-homing Peptides
TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.
7-week-old NOD-SCID mouse
mRNA display library
Additional Detail Fields 2 fields
CIIIIISGGGSCC
7-week-old NOD-SCID mouse