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Peptide record

TPDB64401

cyclic [WH]5 linear (WH)5 Cell-penetrating Peptides standard
10 amino acids
Basic Information
3D PDB MODEL
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TPDB64401
cyclic [WH]5 linear (WH)5
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 10-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
WHWHWHWHWH
Physicochemical Analysis
C85H87N25O11
ARNDCEQGILKMFPSTYV
HW
1634.79
8.20
5
0
5
+0
-4.45
-2.050
0.00
Mammalian: 2.8 hour Yeast: 3 min E.coli: 2 min
27500
1682.18
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
5
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
5
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 5 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 5 Y: 0 V: 0
Chemical Descriptors
10
C85H87N25O11
1634.79
8.20
+0
-4.45
-2.050
Free
L
Linear Cyclic
Free
N[C@@H](CS)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)O N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)O
Evidence Records 4 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Sk-Ov-3 And CCRF-CEM Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
CF-labelled GpYEEI and emtricitabine (FTC)
Cytosol
The cellular uptake of F’-GpYEEI was enhanced 9 fold by c[WH]5 compared to that of the phosphopeptide alone.
Direct translocation
In vitro
CCCCCCCCC
Evidence 2 Activity

Activity

Cell-penetrating Peptides

Target

Sk-Ov-3 And CCRF-CEM Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Cyclic L
Synthetic
CF-labelled GpYEEI and emtricitabine (FTC)
Cytosol
The cellular uptake of F’-GpYEEI was enhanced 2.3 fold by l(WH)5 compared to that of the phosphopeptide alone.
Direct translocation
In vitro
CCCCC
Evidence 3 Activity

Activity

Cell-penetrating Peptides

Target

Sk-Ov-3 And CCRF-CEM Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L
Synthetic
CF-labeled anti-HIV drug, emtricitabine (F’-FTC)
Cytosol
Intracellular uptake of F’-FTC by linear (WH)5 in SK-OV-3 enhanced by 3.5-fold compared to that of the drug alone.
Direct translocation
In vitro
CCCCC
Evidence 4 Activity

Activity

Cell-penetrating Peptides

Target

Sk-Ov-3 And CCRF-CEM Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Cyclic L
Synthetic
CF-labeled anti-HIV drug, emtricitabine (F’-FTC)
Cytosol
Intracellular uptake of F’-FTC by cyclic [WH]5 in SK-OV-3 enhanced by 9-fold compared to that of the drug alone.
Direct translocation
In vitro
CCCCC
Additional Detail Fields 1 fields
CCCCCCCCC CCCCC