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Peptide record

TPDB64399

cpp = oligoarginine sample S0(GNRs@PEG@CPP) sample S30 (GNRs@sil@PEG@CPP) Cell-penetrating Peptides standard
23 amino acids
Basic Information
3D PDB MODEL
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TPDB64399
cpp = oligoarginine sample S0(GNRs@PEG@CPP) sample S30 (GNRs@sil@PEG@CPP)
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 23-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation N-terminal: Acetylation
Sequence
Ac-WGRRVRRRIRRPPPPPPPPPGGK-NH2
Physicochemical Analysis
C121H200N46O24
ANDCEQHLMFSTY
P
2683.21
13.18
8
0
3
+8
8.65
-1.878
29.57
Mammalian: 2.8 hour Yeast: 3 min E.coli: 2 min
5500
204.98
0
Residue Composition
number
0
A
7
R
0
N
0
D
0
C
0
E
0
Q
3
G
0
H
1
I
0
L
1
K
0
M
0
F
9
P
0
S
0
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 7 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 3 H: 0 I: 1 L: 0 K: 1 M: 0 F: 0 P: 9 S: 0 T: 0 W: 1 Y: 0 V: 1
Chemical Descriptors
23
C121H200N46O24
2683.21
13.18
+8
8.65
-1.878
Amidation
L
Linear
Acetylation
N[C@@H](CCCCN)C(=O)N[C@H](CCC(=O)O)C(=O)N[C@@H]([C@H](C)O)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H]([C@H](C)O)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@H]([C@H](C)O)C(=O)N[C@H](CCC(=O)O)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@H](CO)C(=O)N[C@@H](CCC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(C)C)C1OO1 N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)NCC(=O)NCC(=O)N[C@@H](CCCCN)C(=O)O
Evidence Records 2 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

J774A.1 Murine Macrophages

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
gold nanorods (GNRs)
Samples S0 in the presence of a thin shell of organosilica, the mass of gold per cell seems to be a little higher at shorter incubation times to a value in the order of 2–3 pg Au.
In vitro
CCSSCCCCCCCCCCCSSCCCC
Evidence 2 Activity

Activity

Cell-penetrating Peptides

Target

J774A.1 Murine Macrophages

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L
Synthetic
gold nanorods (GNRs)
The mass of gold per cell in the case of sample S30 reaches a value that is about 3 times lower than those of case S0.
In vitro
CCTTGGGGSCCCSSSSSCCGGGC
Additional Detail Fields 1 fields
CCSSCCCCCCCCCCCSSCCCC CCTTGGGGSCCCSSSSSCCGGGC