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Peptide record

TPDB64391

peptide pair 3 Cell-penetrating Peptides standard
20 amino acids
Basic Information
3D PDB MODEL
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TPDB64391
peptide pair 3
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 20-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Chemical: Nanoparticle
Sequence
WERLARALARALARLLARAR
Physicochemical Analysis
C103H181N39O23
NDCQGHIKMFPSTYV
A
2333.82
12.70
6
1
13
+5
1.04
0.010
132.50
Mammalian: 2.8 hour Yeast: 3 min E.coli: 2 min
5500
235.67
0
Residue Composition
number
7
A
6
R
0
N
0
D
0
C
1
E
0
Q
0
G
0
H
0
I
5
L
0
K
0
M
0
F
0
P
0
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 7 R: 6 N: 0 D: 0 C: 0 E: 1 Q: 0 G: 0 H: 0 I: 0 L: 5 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
20
C103H181N39O23
2333.82
12.70
+5
1.04
0.010
Free
Nanoparticle
L
Cationic and amphipathic
Linear
Free
N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

MCF-7 And MDA-MB-231 Breast Cancer Cells Pc-3 And Du145 Prostate Cancer Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic and amphipathic
Synthetic
pEGFP-N1
Pep 3 was no more efficient than naked DNA in both cell lines (S6E).
In vitro
CCHHHHHHHHHHHHHHHHHTTC
Additional Detail Fields 1 fields
CCHHHHHHHHHHHHHHHHHTTC