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Peptide record

TPDB64381

RRRR Cell-penetrating Peptides standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB64381
RRRR
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 13-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Chemical: Nanoparticle
Sequence
WEGRRRRRRRCEA
Physicochemical Analysis
C71H123N35O18S1
NDQHILKMFPSTYV
R
1787.04
12.28
7
2
2
+5
7.46
-2.731
7.69
Mammalian: 2.8 hour Yeast: 3 min E.coli: 2 min
5500
307.77
1
Residue Composition
number
1
A
7
R
0
N
0
D
1
C
2
E
0
Q
1
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 7 N: 0 D: 0 C: 1 E: 2 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
13
C71H123N35O18S1
1787.04
12.28
+5
7.46
-2.731
Free
Nanoparticle
L
Cationic
Linear
Free
N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCC(=O)O)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Dc2.4 Cells

Assay & Model

Female wild type C57BL/6 mice, Ifnar−/− mice, OT-I mice, C57BL/6 luciferase reporter mice (IFN-β+/Δβ-luc)
Female wild type C57BL/6 mice, Ifnar−/− mice, OT-I mice, C57BL/6 luciferase reporter mice (IFN-β+/Δβ-luc)

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Synthetic
Cy3b-mRNA( eGFP (unmod: L-6301 mod: L-6303) and ovalbumin)
Endocytic Vesicles
RRRR enabling the intermediate mRNA uptake.
In vitro and in vivo
CCSCGGGCCSSCTTSCCCCCCCCCCCSCC
Additional Detail Fields 1 fields
CCSCGGGCCSSCTTSCCCCCCCCCCCSCC