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Peptide record

TPDB64378

RALA Cell-penetrating Peptides standard
30 amino acids
Basic Information
3D PDB MODEL
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TPDB64378
RALA
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 30-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Chemical: Nanoparticles
Sequence
WEARLARLALRALARHLARALARALRACEA
Physicochemical Analysis
C147H254N54O35S1
NDQGIKMFPSTYV
A
3370.03
12.28
8
2
19
+5
2.79
0.210
127.67
Mammalian: 2.8 hour Yeast: 3 min E.coli: 2 min
5500
163.20
1
Residue Composition
number
11
A
7
R
0
N
0
D
1
C
2
E
0
Q
0
G
1
H
0
I
7
L
0
K
0
M
0
F
0
P
0
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 11 R: 7 N: 0 D: 0 C: 1 E: 2 Q: 0 G: 0 H: 1 I: 0 L: 7 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
30
C147H254N54O35S1
3370.03
12.28
+5
2.79
0.210
Free
Nanoparticles
L
Amphipathic
Linear
Free
N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CC(=O)N)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Hct116 Crc And Ht29 Crc Cell Lines

Assay & Model

BALB/c SCID mice
BALB/c SCID mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Amphipathic
Synthetic
P4-SedU2, P4-SeT2
RALA/P4-SedU2 NPs into tissues indicates a rapid process of cellular uptake than less than the P4-SedU2.
In vitro and in vivo
CCTTHHHHSCSTTTTTSSSSCCSCCC
Additional Detail Fields 1 fields
CCTTHHHHSCSTTTTTSSSSCCSCCC