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Peptide record

TPDB64377

RALA-E Cell-penetrating Peptides standard
36 amino acids
Basic Information
3D PDB MODEL
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TPDB64377
RALA-E
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 36-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
WEARLARALARALARHLARALARALRACEAVGVAPG
Physicochemical Analysis
C166H284N60O41S1
NDQIKMFSTY
A
3808.52
12.28
8
2
22
+5
3.62
0.336
117.22
Mammalian: 2.8 hour Yeast: 3 min E.coli: 2 min
5500
144.41
1
Residue Composition
number
13
A
7
R
0
N
0
D
1
C
2
E
0
Q
2
G
1
H
0
I
6
L
0
K
0
M
0
F
1
P
0
S
0
T
1
W
0
Y
2
V
Amino Acid Distribution
A: 13 R: 7 N: 0 D: 0 C: 1 E: 2 Q: 0 G: 2 H: 1 I: 0 L: 6 K: 0 M: 0 F: 0 P: 1 S: 0 T: 0 W: 1 Y: 0 V: 2
Chemical Descriptors
36
C166H284N60O41S1
3808.52
12.28
+5
3.62
0.336
Free
L
Linear
Free
N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Hek-293T, HeLa And THP-1 Cell Lines

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Fusogenic
GFP-tagged pDNA and FAM-miR-146a
Nucleus
Transfection efficiency of RALA-E group was close to 60% in HEK-293T cell and 45% in HeLa cells.
Caveolae-mediated and lipid raft-mediated endocytosis
In vitro
CCCSSHHHHHHHHHSCTHHHHHHHTTCTTSCCSCC
Additional Detail Fields 1 fields
CCCSSHHHHHHHHHSCTHHHHHHHTTCTTSCCSCC