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Peptide record

TPDB64373

HALA4 Cell-penetrating Peptides standard
30 amino acids
Basic Information
3D PDB MODEL
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TPDB64373
HALA4
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 30-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
WEARLARALARALARHLAHALAHALHACEA
Physicochemical Analysis
C144H233N51O35S1
NDQGIKMFPSTYV
A
3270.81
10.74
8
2
19
+2
3.63
0.273
118.00
Mammalian: 2.8 hour Yeast: 3 min E.coli: 2 min
5500
168.15
1
Residue Composition
number
12
A
4
R
0
N
0
D
1
C
2
E
0
Q
0
G
4
H
0
I
6
L
0
K
0
M
0
F
0
P
0
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 12 R: 4 N: 0 D: 0 C: 1 E: 2 Q: 0 G: 0 H: 4 I: 0 L: 6 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
30
C144H233N51O35S1
3270.81
10.74
+2
3.63
0.273
Free
L
Linear
Free
N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa, A549, And HEK-293T Cell Line

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
5'Cy3-modified non-target siRNA and pCMV-Enhanced Green Fluorescent Protein (EGFP) plasmid DNA
pDNA transfection of HALA4 group was less than RALA and HALA1 in HeLa and A549 cells.
More than one endocytosis pathways
In vitro
CCCSSHHHHHHHHHSCCCCCSSSSCC
Additional Detail Fields 1 fields
CCCSSHHHHHHHHHSCCCCCSSSSCC