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Peptide record

TPDB64372

DEN-K(KALA)-TAT (Pep 10) Cell-penetrating Peptides standard
43 amino acids
Basic Information
3D PDB MODEL
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TPDB64372
DEN-K(KALA)-TAT (Pep 10)
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 43-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation Chemical: Poly-L-lysine dendrons (DEN)
Sequence
WEAKLAKALAKALAKHLAKALAKALKACEAGRKKRRQRRRPPQ-NH2
Physicochemical Analysis
C214H377N75O50S1
NDIMFSTYV
A
4832.88
12.16
16
2
19
+13
13.35
-0.858
82.33
Mammalian: 2.8 hour Yeast: 3 min E.coli: 2 min
5500
113.80
3
Residue Composition
number
12
A
6
R
0
N
0
D
1
C
2
E
2
Q
1
G
1
H
0
I
6
L
9
K
0
M
0
F
2
P
0
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 12 R: 6 N: 0 D: 0 C: 1 E: 2 Q: 2 G: 1 H: 1 I: 0 L: 6 K: 9 M: 0 F: 0 P: 2 S: 0 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
43
C214H377N75O50S1
4832.88
12.16
+13
13.35
-0.858
Amidation
Poly-L-lysine dendrons (DEN)
L
Cationic
Linear
Free
N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Chimeric
YOYO-1 labelled pEGFP plasmid
Cytoplasm and nucleus
Improved cellular uptake of pep 10 was ∼65% at N/P 5
In vitro
CCCCSCCCCCC
Additional Detail Fields 1 fields
CCCCSCCCCCC