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Peptide record

TPDB64371

KALA Cell-penetrating Peptides standard
27 amino acids
Basic Information
3D PDB MODEL
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TPDB64371
KALA
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 27-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Chemical: Vitamin E-scaffolds (ssPalmE) for lipid nanoparticle (LNP) N-terminal: Stearylation
Sequence
WEAKLAKALAKALAKHLAKALAKALKA
Physicochemical Analysis
C133H231N37O30
RNDCQGIMFPSTYV
A
2828.53
10.92
8
1
18
+6
2.83
0.285
127.41
Mammalian: 2.8 hour Yeast: 3 min E.coli: 2 min
5500
194.45
0
Residue Composition
number
11
A
0
R
0
N
0
D
0
C
1
E
0
Q
0
G
1
H
0
I
6
L
7
K
0
M
0
F
0
P
0
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 11 R: 0 N: 0 D: 0 C: 0 E: 1 Q: 0 G: 0 H: 1 I: 0 L: 6 K: 7 M: 0 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
27
C133H231N37O30
2828.53
10.92
+6
2.83
0.285
Free
Vitamin E-scaffolds (ssPalmE) for lipid nanoparticle (LNP)
L
Cationic
Linear
Stearylation
N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCC(=O)O)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

E.G7-Ova Cells, Murine Bmdcs , Fresh Rbcs Of Icr Mice

Assay & Model

C57BL/6 mice
C57BL/6 mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
mRNA (Luc and OVA)
Cytoplasm
The cellular uptake of the ssPalmE-KALA was significantly higher than that of the ssPalmE-R8.
In vitro and in vivo
CCSSSSGGGTCCC
Additional Detail Fields 1 fields
CCSSSSGGGTCCC