Back to search

Peptide record

TPDB64357

VG-21 Cell-penetrating Peptides standard
21 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB64357
VG-21
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0 MLCPP 2.0 Peptipedia PerseuCPP
standard
No
A 21-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, MLCPP 2.0, Peptipedia, and other sources, with an available 3D structural model.
Sequence
VTPHHVLVDEYTGEWVDSQFK
Physicochemical Analysis
C114H164N28O35
ARNCIM
V
2486.72
4.52
3
4
8
-3
6.66
-0.514
73.81
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
6990
281.09
5
Residue Composition
number
0
A
0
R
0
N
2
D
0
C
2
E
1
Q
1
G
2
H
0
I
1
L
1
K
0
M
1
F
1
P
1
S
2
T
1
W
1
Y
4
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 2 C: 0 E: 2 Q: 1 G: 1 H: 2 I: 0 L: 1 K: 1 M: 0 F: 1 P: 1 S: 1 T: 2 W: 1 Y: 1 V: 4
Chemical Descriptors
21
C114H164N28O35
2486.72
4.52
-3
6.66
-0.514
Free
L
Linear
Free
N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HEp-2, HeLa, Vero and Cos-7 cells

Assay & Model

BALB/c mice
BALB/c mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Protein derived
Fluorophore (FITC)
Cytoplasm, Nucleus and Vesicles
HeLa and HEp-2 cells expressed higher percentage of FITC-positive cells as compared to Vero and Cos- 7 cells
In vitro and in vivo
CCSCCCSSCTTTTTTCCCC
Additional Detail Fields 1 fields
CCSCCCSSCTTTTTTCCCC