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Peptide record

TPDB64354

VS( L-enantiomer) Cell-penetrating Peptides standard
15 amino acids
Basic Information
3D PDB MODEL
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TPDB64354
VS( L-enantiomer)
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 15-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
VSWFSRHRYSPFAVS
Physicochemical Analysis
C86H120N24O21
NDCEQGILKMT
S
1826.05
11.16
3
0
7
+2
-1.53
-0.227
45.33
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
6990
382.79
5
Residue Composition
number
1
A
2
R
0
N
0
D
0
C
0
E
0
Q
0
G
1
H
0
I
0
L
0
K
0
M
2
F
1
P
4
S
0
T
1
W
1
Y
2
V
Amino Acid Distribution
A: 1 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 1 I: 0 L: 0 K: 0 M: 0 F: 2 P: 1 S: 4 T: 0 W: 1 Y: 1 V: 2
Chemical Descriptors
15
C86H120N24O21
1826.05
11.16
+2
-1.53
-0.227
Free
L
Linear
Free
N[C@@H](CS)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HUVEC And U87 Cells

Assay & Model

U87 tumor BALB/c nude mice
U87 tumor BALB/c nude mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
FAM-labelled micelles loaded Doxorubicin (DOX)
The percentage of fluorescein in positive cells after treatments with L-VS-FAM was 64.09% for U87 cells, and 40.50% for HUVEC cells,
In vitro and in vivo
CCCCGGGCCCC
Additional Detail Fields 1 fields
CCCCGGGCCCC