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Peptide record

TPDB64352

Protamine Cell-penetrating Peptides standard
15 amino acids
Basic Information
3D PDB MODEL
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TPDB64352
Protamine
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0 Peptipedia PerseuCPP
standard
No
A 15-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, Peptipedia, and PerseuCPP, with an available 3D structural model.
N-terminal: Conjugation with 5-carboxyfluorescein via a lysine residue
Sequence
VSRRRRRRGGRRRRK
Physicochemical Analysis
C78H154N46O17
ANDCEQHILMFPTWY
R
2008.38
13.36
11
0
1
+11
9.31
-3.087
19.33
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
1
Residue Composition
number
0
A
10
R
0
N
0
D
0
C
0
E
0
Q
2
G
0
H
0
I
0
L
1
K
0
M
0
F
0
P
1
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 10 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 0 L: 0 K: 1 M: 0 F: 0 P: 0 S: 1 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
15
C78H154N46O17
2008.38
13.36
+11
9.31
-3.087
Free
L
Cationic
Linear
Conjugation with 5-carboxyfluorescein via a lysine residue
N[C@@H](C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Wong-Kilbourne-derived human conjunctival epithelial cells (NHC)

Assay & Model

Male SpragueDawley rats and male albino rabbits
Male SpragueDawley rats and male albino rabbits

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Synthetic
Fluorophore [5-carboxyfluorescein (FAM)]
Lower uptake efficiency
In vitro and in vivo
CCSSCSSCGGGGSCC
Additional Detail Fields 1 fields
CCSSCSSCGGGGSCC