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Peptide record

TPDB64350

LMWP (low molecular weight protamine) Cell-penetrating Peptides standard
15 amino acids
Basic Information
3D PDB MODEL
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TPDB64350
LMWP (low molecular weight protamine)
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 15-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Addition of Cysteine Chemical: PLA−PEG (poly(lactic acid)−methoxy poly(ethylene glycol)
Sequence
VSRRRRRRGGRRRRC
Physicochemical Analysis
C75H147N45O17S1
ANDEQHILKMFPTWY
R
1983.34
13.00
10
0
1
+10
8.08
-2.660
19.33
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
2
Residue Composition
number
0
A
10
R
0
N
0
D
1
C
0
E
0
Q
2
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
1
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 10 N: 0 D: 0 C: 1 E: 0 Q: 0 G: 2 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 1 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
15
C75H147N45O17S1
1983.34
13.00
+10
8.08
-2.660
Addition of Cysteine
PLA−PEG (poly(lactic acid)−methoxy poly(ethylene glycol)
L
Cationic
Linear
Free
N[C@@H](C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CS)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Caco-2 Cells Or Ht29 Cells

Assay & Model

Male diabetic Sprague Dawley (SD) rats (200 ± 20 g)
Male diabetic Sprague Dawley (SD) rats (200 ± 20 g)

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Synthetic
Insulin
INS@MSN@PLA−PEG-CPP showed the highest cellular uptake at 1 h and was about 9.1-, 2.7-, and 2.5-folds than that of the INS solution, INS@MSN, and INS@MSN@ PLA−PEG, respectively.
HSPG receptor-mediated endocytosis, adsorptive, caveolae-mediated, or active endocytosis
In vitro and in vivo
CCCCSSSSGGGGTCC
Additional Detail Fields 1 fields
CCCCSSSSGGGGTCC