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Peptide record

TPDB64337

N50-sC18* Cell-penetrating Peptides standard
22 amino acids
Basic Information
3D PDB MODEL
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TPDB64337
N50-sC18*
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 22-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation
Sequence
VQRKRQKLMPGLRKRLRKFRNK-NH2
Physicochemical Analysis
C124H226N48O26S1
ADCEHISTWY
R
2837.52
13.11
11
0
6
+11
8.88
-1.759
66.36
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
3
Residue Composition
number
0
A
6
R
1
N
0
D
0
C
0
E
2
Q
1
G
0
H
0
I
3
L
5
K
1
M
1
F
1
P
0
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 6 N: 1 D: 0 C: 0 E: 0 Q: 2 G: 1 H: 0 I: 0 L: 3 K: 5 M: 1 F: 1 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
22
C124H226N48O26S1
2837.52
13.11
+11
8.88
-1.759
Amidation
L
Linear
Free
N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

MCF-7 And HeLa Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Chimeric
5(6)-carboxyfluorescein and Doxorubicin
Cytosol, Nuclei And Nucleoli
Extremely high uptake compared to the CPP sC18*
Direct translocation and endocytosis
In vitro
CCSCCCTTTSSCC
Additional Detail Fields 1 fields
CCSCCCTTTSSCC