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Peptide record

TPDB64336

NLS CB5005N Cell-penetrating Peptides standard
10 amino acids
Basic Information
3D PDB MODEL
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TPDB64336
NLS CB5005N
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CellPPD CellPPD-MOD CPPsite3.0 Peptipedia
standard
No
A 10-aa standard natural cell-penetrating peptides peptide sequence curated from CellPPD, CellPPD-MOD, CPPsite3.0, and other sources, with an available 3D structural model.
Sequence
VQRKRQKLMP
Physicochemical Analysis
C55H102N20O13S1
ANDCEGHIFSTWY
RQK
1283.60
12.42
4
0
3
+4
4.49
-1.550
68.00
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
2
Residue Composition
number
0
A
2
R
0
N
0
D
0
C
0
E
2
Q
0
G
0
H
0
I
1
L
2
K
1
M
0
F
1
P
0
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 2 G: 0 H: 0 I: 0 L: 1 K: 2 M: 1 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
10
C55H102N20O13S1
1283.60
12.42
+4
4.49
-1.550
Free
L
Cationic
Linear
Free
N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)O
Evidence Records 2 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
[Ru(bpy)2(dppz)]2+ derivatives via aminohexyl (ahx) bridge
Nucleus
Ru-NLS, reached cytoplasmic structures after 2 h (40 mm complex) but required approximately 24 h to penetrate the nuclear envelope and bind to chromosomal DNA.
Endocytosis
In vitro
CCCSSSTTCCCTTTTC
Evidence 2 Activity

Activity

Cell-penetrating Peptides

Target

bEnd.3, U87 Excised Mice Brain

Assay & Model

Nude mice model bearing U87 xenograft
Nude mice model bearing U87 xenograft

Source & Reference

CPPsite3.0
CPPsite3

Other

Non-natural residues Linear L Cationic
Synthetic
5-carboxyfluorescein (FAM) dye and Doxorubicin (DOX)
Not internalized by both of the cells (<1%)
Endocytosis
In-vitro, in-vivo and ex vivo
Additional Detail Fields 1 fields
CCCSSSTTCCCTTTTC