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Peptide record

TPDB64331

M630 Cell-penetrating Peptides standard
15 amino acids
Basic Information
3D PDB MODEL
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TPDB64331
M630
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CellPPD CellPPD-MOD CPPsite3.0 MLCPP 2.0 Peptipedia PerseuCPP
standard
No
A 15-aa standard natural cell-penetrating peptides peptide sequence curated from CellPPD, CellPPD-MOD, CPPsite3.0, and other sources, with an available 3D structural model.
C-terminal: Amidation N-terminal: Conjugation with fluorescein
Sequence
VQAILRRNWNQYKIQ-NH2
Physicochemical Analysis
C87H140N28O22
DCEGHMFPST
Q
1930.24
11.39
3
0
7
+3
1.12
-0.920
104.00
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
6990
362.13
6
Residue Composition
number
1
A
2
R
2
N
0
D
0
C
0
E
3
Q
0
G
0
H
2
I
1
L
1
K
0
M
0
F
0
P
0
S
0
T
1
W
1
Y
1
V
Amino Acid Distribution
A: 1 R: 2 N: 2 D: 0 C: 0 E: 0 Q: 3 G: 0 H: 0 I: 2 L: 1 K: 1 M: 0 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 1 V: 1
Chemical Descriptors
15
C87H140N28O22
1930.24
11.39
+3
1.12
-0.920
Amidation
L
Linear
Conjugation with fluorescein
N[C@@H](C(C)C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(=O)N)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Human SH-SY5Y, N2A and Human bowes melanoma cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Protein derived
Fluorophore (fluorescein)
Lower than penetratin
In vitro
CCHHHHTCCCSSCCC
Additional Detail Fields 1 fields
CCHHHHTCCCSSCCC