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Peptide record

TPDB64330

VPT Cell-penetrating Peptides standard
5 amino acids
Basic Information
3D PDB MODEL
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TPDB64330
VPT
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CellPPD CPPsite3.0 Peptipedia PerseuCPP
standard
No
A 5-aa standard natural cell-penetrating peptides peptide sequence curated from CellPPD, CPPsite3.0, Peptipedia, and other sources, with an available 3D structural model.
Sequence
VPTLQ
Physicochemical Analysis
C25H44N6O8
ARNDCEGHIKMFSWY
QLPTV
556.66
6.02
0
0
2
-0
0.68
0.440
136.00
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
2
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
1
Q
0
G
0
H
0
I
1
L
0
K
0
M
0
F
1
P
0
S
1
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 0 L: 1 K: 0 M: 0 F: 0 P: 1 S: 0 T: 1 W: 0 Y: 0 V: 1
Chemical Descriptors
5
C25H44N6O8
556.66
6.02
-0
0.68
0.440
Free
L
Neutral
Linear
Free
N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)N)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

MCF-7, HeLa, Hepg2 And MCF-7/Adr Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Neutral
Protein derived
Nucleus
CsA internalization was 4.7-fold higher for PFV and 6.8-fold higher for VPT in HeLa cells 5.6-fold higher for PFV and 19.1-fold higher for VPT in MCF-7 cells
In vitro
CCSCC
Additional Detail Fields 1 fields
CCSCC