Back to search

Peptide record

TPDB64329

CPPGRD Cell-penetrating Peptides standard
26 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB64329
CPPGRD
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 26-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
VPTLKFVIFLDVKHFSPEDLTVKGRD
Physicochemical Analysis
C141H222N34O38
ANCQMWY
V
3001.52
7.77
5
4
11
+0
6.67
0.073
104.62
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
3
Residue Composition
number
0
A
1
R
0
N
3
D
0
C
1
E
0
Q
1
G
1
H
1
I
3
L
3
K
0
M
3
F
2
P
1
S
2
T
0
W
0
Y
4
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 3 C: 0 E: 1 Q: 0 G: 1 H: 1 I: 1 L: 3 K: 3 M: 0 F: 3 P: 2 S: 1 T: 2 W: 0 Y: 0 V: 4
Chemical Descriptors
26
C141H222N34O38
3001.52
7.77
+0
6.67
0.073
Free
L
Linear
Free
N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Cos-7 Cells And ARPE-19 Cell

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Chimeric
FITC–labeled
After 20 minutes of treatment the CPPGRD penetrated Cos-7 cells 3 times more (1.47E+5 fluorescence units) than did the mini-αA peptide (5.0E+4 fluorescence units).
In vitro
CCCSHHHHHHTTCTTTTHHHHHSSSTTCCCCCCSCCCC
Additional Detail Fields 1 fields
CCCSHHHHHHTTCTTTTHHHHHSSSTTCCCCCCSCCCC