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Peptide record

TPDB64326

Penetrating peptide Cell-penetrating Peptides standard
4 amino acids
Basic Information
3D PDB MODEL
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TPDB64326
Penetrating peptide
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 4-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
VPTL
Physicochemical Analysis
C20H36N4O6
ARNDCEQGHIKMFSWY
LPTV
428.53
6.02
0
0
2
-0
0.10
1.425
170.00
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
1
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
1
L
0
K
0
M
0
F
1
P
0
S
1
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 1 K: 0 M: 0 F: 0 P: 1 S: 0 T: 1 W: 0 Y: 0 V: 1
Chemical Descriptors
4
C20H36N4O6
428.53
6.02
-0
0.10
1.425
Free
L
Linear
Free
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Vertical-Type Franz Diffusion Cells

Assay & Model

Male Wistar rats
Male Wistar rats

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Non-natural residues Linear L
Synthetic
mini-αA-crystallin (MAC) and GRD peptide
MAC-GRD peptide showed higher permeation in rat skin (280 μg/cm2 or 23.33% at 8 h) than the 1.2 mg MAC peptide (54 μg/cm2 or 4.5% at 8 h),
In vivo and ex vivo