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Peptide record

TPDB64317

VPALR Blood-Brain Barrier Cell-penetrating Peptides standard
5 amino acids
Basic Information
3D PDB MODEL
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TPDB64317
VPALR
Blood-Brain Barrier Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
BBPpredict CellPPD CPPsite3.0 Peptipedia PerseuCPP
standard
No
A 5-aa standard natural multi-activity (Blood-Brain Barrier and Cell-penetrating Peptides) peptide sequence curated from BBPpredict, CellPPD, CPPsite3.0, and other sources, with an available 3D structural model.
Sequence
VPALR
Physicochemical Analysis
C25H46N8O6
NDCEQGHIKMFSTWY
ARLPV
554.69
11.05
1
0
3
+1
0.60
0.740
156.00
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
0
Residue Composition
number
1
A
1
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
1
L
0
K
0
M
0
F
1
P
0
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 1 K: 0 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
5
C25H46N8O6
554.69
11.05
+1
0.60
0.740
Free
L
Linear
Free
N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCN=C)C(=O)O N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 2 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Ht22 Cells And bEnd.3 Cells

Assay & Model

ICR mice
ICR mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Protein derived
Sulpiride (SUL)
Concentration of sulpiride in the VPALR-SUL group into cells was 1.27 and 1.43 times at 1 and 4 h in HT22 cells while in bEnd.3 cells was 2.25 and 3.87 times for 1 and 4 h than the sulpiride group
In vitro and in vivo
CCCCCTTHHHHCC
Evidence 2 Activity

Activity

Cell-penetrating Peptides

Target

Ht22 Cells And bEnd.3 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L
Protein derived
5-TAMRA
Cytosol
Time-dependent internalized of dye into the cells by means of VPALR-mediated transport in both cells
In vitro
CCSCC
Additional Detail Fields 1 fields
CCCCCTTHHHHCC CCSCC