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Peptide record

TPDB64313

p5RHH Cell-penetrating Peptides standard
21 amino acids
Basic Information
3D PDB MODEL
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TPDB64313
p5RHH
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0 MLCPP 2.0 Peptipedia
standard
No
A 21-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, MLCPP 2.0, and Peptipedia, with an available 3D structural model.
Sequence
VLTTGLPALISWIRRRHRRHC
Physicochemical Analysis
C112H189N41O25S1
NDEQKMFY
R
2542.05
12.58
7
0
8
+5
2.35
-0.243
111.43
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
5500
216.36
4
Residue Composition
number
1
A
5
R
0
N
0
D
1
C
0
E
0
Q
1
G
2
H
2
I
3
L
0
K
0
M
0
F
1
P
1
S
2
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 5 N: 0 D: 0 C: 1 E: 0 Q: 0 G: 1 H: 2 I: 2 L: 3 K: 0 M: 0 F: 0 P: 1 S: 1 T: 2 W: 1 Y: 0 V: 1
Chemical Descriptors
21
C112H189N41O25S1
2542.05
12.58
+5
2.35
-0.243
Free
L
Amphipathic
Linear
Free
N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Hek293T And Ct26.Cl25 Cell Lines

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Amphipathic
5-methoxyuridine-modified mCherry mRNA, Enhanced green fluorescence protein (EGFP) mRNA and Ovalbumin (OVA) mRNA
Cytoplasm
Higher mRNA uptake efficiencies to Lipofectamine were observed for STR-Arg8 (83.7%), p5RHH (86.7%) and RALA (99.9%)-mediated mRNA complexes.
In vitro
CCCCCCCC
Additional Detail Fields 1 fields
CCCCCCCC